Available Online: 31 May 2026
Spatial Profiling of the Head and Neck Squamous Cell Carcinoma Microenvironment: Reshaping Our Understanding and Therapeutic Opportunities
Volume 3
Head and neck squamous cell carcinoma (HNSCC) is characterized by a highly heterogeneous tumor microenvironment (TME) that drives disease progression and therapeutic resistance. The emergence of spatial omics technology, encompassing spatial transcriptomics, proteomics, metabolomics and multi-modal imaging, has revolutionized our understanding of TME by preserving the critical spatial architecture of molecular landscapes. This review synthesizes key innovations derived from spatial omics in HNSCC TME, detailing the organised spatial distribution of..