Perspective

Available Online: 07 May 2026

Chrono-Adaptive Resistance Disruption (CARD): A Novel Pharmacological Framework to Address Anticancer Drug Resistance

Volume 2

Drug resistance in anticancer therapy has long remained an open problem in biomedical and pharmacological research in oncology. Nevertheless, despite numerous efforts aimed at targeting biological mechanisms at the molecular and pathway levels and testing various combination therapies, the present pharmacological approach has remained largely stagnant and insensitive to changes in circadian rhythms of tumor biology and drug resistance. However, an emerging body of preclinical and clinical data suggests that..