Available Online: 25 Jun 2026
Chitosan Nanoparticle Delivery of Prunus africana (Hook.f) Kalkman Attenuates TGF-β/SMAD3-Driven Epithelial–Mesenchymal Transition to Suppress Prostate Cancer Metastasis
Volume 2
Background: As is well known, one of the major drivers of metastatic prostate cancer is the epithelial-mesenchymal transition (EMT), which is tightly controlled by TGF-β/SMAD3 signaling. Therefore, although Prunus africana, which contains active phytochemicals with anticancer potential, is a drug candidate with poor solubility and limited bioavailability, these limitations may hamper its efficacy in clinical use. Aim: In this study, the team assessed whether vending the extract, P. africana, with..