Volume 2

Review Article

Available Online: 31 Mar 2026

AI-Enabled Generative Design of Immune Cells and Receptors for Programmable Immunity

Volume 2

Recent advances in generative artificial intelligence have begun to reshape the field of cell and immune engineering. By learning the statistical and structural principles underlying biological systems, generative models can now design T-cell receptors, chimeric antigen receptors, and synthetic immune circuits that satisfy complex requirements for affinity, stability, and specificity. When integrated into automated design–build–test–learn pipelines, these models facilitate iterative cycles of hypothesis generation, experimental validation, and model refinement, thereby..